Catalytic Asymmetric Nucleophilic Addition of 3-Vinyl Indoles to Imines
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- 作者：Jia-Hui Xue ; Ming Shi ; Feng Yu ; Xiao-Yun Li ; Wen Ren ; Li-Na Fu ; Qi-Xiang Guo
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：August 5, 2016
- 年：2016
- 卷：18
- 期：15
- 页码：3874-3877
- 全文大小：298K
- 年卷期：0
- ISSN：1523-7052
文摘
The 3-vinyl indole is used as a nucleophile to react with aromatic and aliphatic imines. Chiral 3-substituted indoles bearing multiple functional groups are produced with up to 99% yield, a 98:2 E/Z ratio, and 97% ee. A possible mechanism is proposed to explain the observed stereoselectivities. This strategy provides an efficient way for the preparation of novel chiral 3-substituted indoles.