Asymmetric Synthesis of 伪-Amino Ketones by Br酶nsted Acid Catalysis

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• 作者：Wei Wen ; Yu Zeng ; Li-Yu Peng ; Li-Na Fu ; Qi-Xiang Guo
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：17
• 期：15
• 页码：3922-3925
• 全文大小：299K
• ISSN：1523-7052

文摘

The highly efficient, regioselective, and enantioselective transfer hydrogenation of 伪-keto ketimines and reductive amination of diketones by Br酶nsted acid catalysis is described. A series of chiral 伪-amino ketones is prepared in high yields (up to >99%), excellent regioselectivities (up to >99:1), and enantioselectivities (up to 98% ee). This method has broad substrate scope.