An Effective Method for Allylic Oxidation of Δ5-Steroids Using tert-Butyl Hydroperoxide
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- 作者：Yuancheng Li ; Xianghong Wu ; Tae Bum Lee ; Eleanor K. Isbell ; Edward J. Parish ; Anne E. V. Gorden
- 刊名：Journal of Organic Chemistry
- 出版年：2010
- 出版时间：March 5, 2010
- 年：2010
- 卷：75
- 期：5
- 页码：1807-1810
- 全文大小：703K
- 年卷期：v.75,no.5(March 5, 2010)
- ISSN：1520-6904
文摘
An allylic oxidation method for Δ5-steroids using TBHP as oxidant with a 2-quinoxalinol salen Cu(II) complex as catalyst is reported. A variety of Δ5-steroidal substrates are selectively oxidized to the corresponding enones. Excellent yields are achieved (up to 99% under optimized conditions) while significantly reducing reaction times required as compared to other current methods.