Synthesis of 鈥淭wo-Story鈥?Calix[6]aza-Cryptands

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• 作者：Xianshun Zeng ; Claudia Bornholdt ; Diana Over ; Olivia Reinaud
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：October 21, 2011
• 年：2011
• 卷：13
• 期：20
• 页码：5660-5663
• 全文大小：758K
• 年卷期：v.13,no.20(October 21, 2011)
• ISSN：1523-7052

文摘

The first four members of a new family of C_3v-symmetrical 鈥渢wo-story鈥?calix[6]aza-cryptands have been synthesized. These large funnel shaped aza-ligands are formed through introduction of three aromatic arms as spacers onto the small rim of a calix[6]arene and subsequently capped with the tripodal aza caps tacn [1,3,5-triazacyclononane] or tren [tris(aminoethyl)amine]. A key feature for an efficient final 1:1 macrocyclization appears to be an adequate geometrical fit between the extended calixarene scaffold and the aza caps.