Polydopamine Coatings in Confined Nanopore Space: Toward Improved Retention and Release of Hydrophilic Cargo

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• 作者：Xianying Zheng ; Jixi Zhang ; Jie Wang ; Xueqiang Qi ; Jessica M. Rosenholm ; Kaiyong Cai
• 刊名：Journal of Physical Chemistry C
• 出版年：2015
• 出版时间：October 29, 2015
• 年：2015
• 卷：119
• 期：43
• 页码：24512-24521
• 全文大小：595K
• ISSN：1932-7455

文摘

A composite nanocarrier system integrating the porous structure of mesoporous silica nanoparticles (MSNs) and the adhesive property of polydopamine (PDA) for loading and release of hydrophilic drugs is reported. Amino group functionalization facilitates the oxidant-induced surface polymerization of dopamine in the confined space of mesopores by Schiff base/Michael addition reaction in a mild synthesis. As a consequence, MSN@PDA particles have an average pore size of 4.0 nm, a particle diameter of 鈭?0 nm, as well as a thin layer of polydopamine coating on the surfaces of MSNs. The MSN@PDA nanocarriers can effectively adsorb hydrophilic drugs with high loading capacities (380 渭g/mg for doxorubicin hydrochloride (DOX) and 320 渭g/mg for calcein), facilitated by the 蟺鈥撓€ stacking interactions between the abundant aromatic rings of PDA and the aromatic backbones of drugs. Interestingly, sustained and pH-dependent drug release was observed for these drug-loaded MSN@PDA particles, owing to the adhesive property of polydopamine like 鈥渕olecular glue鈥? Moreover, a catechol鈥搈etal鈥揹rug coordination system can be easily constructed on the basis of the coordination bonding between catechols in polydopamine and transition metal ions (Fe³⁺, Zn²⁺) as well as that between metal ions and anthracycline drugs (i.e., DOX), resulting in an acid-triggered drug release.