Solubility of Valsartan in Different Organic Solvents and Ethanol + Water Binary Mixtures from (278.15 to 313.15) K

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• 作者：Yan Liu ; Jingkang Wang* ; Xiaobo Wang ; Peng Liu ; Fei Pang
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2009
• 出版时间：March 12, 2009
• 年：2009
• 卷：54
• 期：3
• 页码：986-988
• 全文大小：81K
• 年卷期：v.54,no.3(March 12, 2009)
• ISSN：1520-5134

文摘

The solubility of valsartan in pure methyl acetate, n-butyl acetate, acetonitrile, N,N-dimethylformamide, dichloromethane, chloroform, and ethanol + water binary mixtures was measured by a synthetic method over the temperature range (278.15 to 313.15) K at atmospheric pressure. The results show that the solubility of valsartan increases with increasing temperature in all six pure solvents and ethanol + water binary mixtures, and it increases with increasing mole fraction of ethanol in the binary mixtures. The experimental data were correlated using the modified Apelblat model, and the agreement with the experimental data was very good.