Fully Automated Continuous Meso-flow Synthesis of 5鈥?Nucleotides and Deoxynucleotides
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- 作者：Chenjie Zhu ; Chenglun Tang ; Zhi Cao ; Wei He ; Yong Chen ; Xiaochun Chen ; Kai Guo ; Hanjie Ying
- 刊名：Organic Process Research & Development
- 出版年：2014
- 出版时间：November 21, 2014
- 年：2014
- 卷：18
- 期：11
- 页码：1575-1581
- 全文大小：368K
- ISSN：1520-586X
文摘
The first continuous meso-flow synthesis of natural and non-natural 5鈥?nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.