Enantioselective Construction of Spirocyclic Oxindole Derivatives with Multiple Stereocenters via an Organocatalytic Michael/Aldol/Hemiacetalization Cascade Reaction
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- 作者：Luyi Zhu ; Qiliang Chen ; Dan Shen ; Weihao Zhang ; Cong Shen ; Xiaofei Zeng ; Guofu Zhong
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：May 20, 2016
- 年：2016
- 卷：18
- 期：10
- 页码：2387-2390
- 全文大小：311K
- 年卷期：0
- ISSN：1523-7052
文摘
An efficient organocatalytic Michael/aldol/hemiacetalization cascade reaction for construction of enantioenriched spirocyclic oxindoles fused with tetrahydropyrane has been developed. The desired highly functionalized 5′,6′-dihydro-2′H,4′H-spiro[indoline-3,3′-pyran]-2-one derivatives containing multiple stereogenic centers were obtained in moderate to high chemical yields and with high stereoselectivities.