Storage of Hydrogen Spin Polarization in Long-Lived 13C2 Singlet Order and Implications for Hyperpolarized Magnetic Resonance Imaging

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• 作者：Yesu Feng ; Thomas Theis ; Xiaofei Liang ; Qiu Wang ; Pei Zhou ; Warren S. Warren
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：July 3, 2013
• 年：2013
• 卷：135
• 期：26
• 页码：9632-9635
• 全文大小：223K
• 年卷期：v.135,no.26(July 3, 2013)
• ISSN：1520-5126

文摘

Hyperpolarized magnetic resonance imaging (MRI) is a powerful technique enabling real-time monitoring of metabolites at concentration levels not accessible by standard MRI techniques. A considerable challenge this technique faces is the T₁ decay of the hyperpolarization upon injection into the system under study. Here we show that A_nA鈥?sub>nXX鈥?spin systems such as ¹³C₂-1,2-diphenylacetylene (¹³C₂-DPA) sustain long-lived polarization for both ¹³C and ¹H spins with decay constants of almost 4.5 min at high magnetic fields of up to 16.44 T without spin-locking; the T₁ of proton polarization is only 3.8 s. Therefore, storage of the proton polarization in a ¹³C₂-singlet state causes a 69-fold extension of the spin lifetime. Notably, this extension is demonstrated with proton-only pulse sequences, which can be readily implemented on standard clinical scanners.