Enantioselective Total Synthesis of (鈭?-Incarviatone A

详细信息    查看全文

• 作者：Benke Hong ; Chao Li ; Zhen Wang ; Jie Chen ; Houhua Li ; Xiaoguang Lei
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：September 23, 2015
• 年：2015
• 卷：137
• 期：37
• 页码：11946-11949
• 全文大小：432K
• ISSN：1520-5126

文摘

We report herein the first total synthesis of (鈭?-incarviatone A (1) in 14 steps starting from commercially available inexpensive phenylacetic acid (9). Our early stage synthesis relies on the scalable and sequential C鈥揌 functionalization to rapidly assemble the indanyl dialdehyde framework. Further biomimetic cascade strategy allows us to obtain the natural product in a one-pot operation. We also conduct detailed mechanistic studies and disclose all the possible intermediates and isomers formed during the biomimetic cascade process.