Direct Regioselective γ-Amination of Enones

详细信息    查看全文

• 作者：Xiaohong Chen ; Xiaoguang Liu ; Justin T. Mohr
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：February 19, 2016
• 年：2016
• 卷：18
• 期：4
• 页码：716-719
• 全文大小：414K
• ISSN：1523-7052

文摘

Carbonyl compounds bearing a γ-amino group are valuable pharmacologically active targets. Regioselective γ-C–N bond formation is achieved with simple enone substrates through controlled dienolate reactivity toward azodicarboxylate electrophiles. The amination reaction occurs readily with sterically demanding nucleophiles and is stereoselective.