Regiocontrolled Oxidative C–C Coupling of Dienol Ethers and 1,3-Dicarbonyl Compounds

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• 作者：Xiaoguang Liu ; Xiaohong Chen ; Justin T. Mohr
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：July 1, 2016
• 年：2016
• 卷：18
• 期：13
• 页码：3182-3185
• 全文大小：352K
• 年卷期：0
• ISSN：1523-7052

文摘

A strategy for synthesis of γ-alkylated enones through oxidative coupling of siloxydienes and 1,3-dicarbonyl compounds is reported. This method is an interrupted form of our formal [3 + 2] cycloaddition method reported previously. The present work excels in generating all-carbon quaternary centers via C–C bond formation at the remote γ-site which is traditionally challenging to functionalize. Stereoselectivity and functional group tolerance are examined in complex systems. Double alkylation reactions are also described.