Synthesis and Cytoxicity of Sempervirine and Analogues

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• 作者：Xiaohong Pan ; Chunying Yang ; John L. Cleveland ; Thomas D. Bannister
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：81
• 期：5
• 页码：2194-2200
• 全文大小：601K
• ISSN：1520-6904

文摘

Sempervirine and analogues were synthesized using a route featuring Sonogashira and Larock Pd-catalyzed reactions. Structure–activity relationships were investigated using three human cancer cell lines. 10-Fluorosempervirine is the most potently cytotoxic member of the family yet described.