Daphmacromines A鈥揓, Alkaloids from Daphniphyllum macropodum
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- 作者：Mingming Cao ; Yu Zhang ; Hongping He ; Shifei Li ; Shengdian Huang ; Duozhi Chen ; Guihua Tang ; Shunlin Li ; Yingtong Di ; Xiaojiang Hao
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：June 22, 2012
- 年：2012
- 卷：75
- 期：6
- 页码：1076-1082
- 全文大小：338K
- 年卷期：v.75,no.6(June 22, 2012)
- ISSN：1520-6025
文摘
Ten new yuzurine-type Daphniphyllum alkaloids, daphmacromines A鈥揓 (1鈥?b>10), along with seven known alkaloids were isolated from the leaves and stems of Daphniphyllum macropodum. Their structures were elucidated by extensive spectroscopic techniques, including 2D NMR spectroscopy and mass spectrometry, and the structure of 1 was confirmed by single-crystal X-ray diffraction. The pesticidal and cytotoxic activities of the isolated alkaloids were evaluated in vitro against brine shrimp (Artemia salina) and five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), respectively. This study also suggested structural revisions of oxodaphnigracine, oxodaphnigraciline, and epioxodaphnigraciline.