Convenient Method for the Synthesis of a Flexible Cyclic Polyamide for Selective Targeting of c-myb G-quadruplex DNA

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• 作者：Qiang Zhang ; Xiaojie Cui ; Sen Lin ; Jiang Zhou ; Gu Yuan
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：December 21, 2012
• 年：2012
• 卷：14
• 期：24
• 页码：6126-6129
• 全文大小：236K
• 年卷期：v.14,no.24(December 21, 2012)
• ISSN：1523-7052

文摘

A convenient efficient method for synthesis of a flexible cyclic polyamide (c尾, 1) was developed through cyclodimerization. Electrospray ionization mass spectrometry and nuclear magnetic resonance results showed that 1 selectively binds to the c-myb G-quadruplex with high affinity, and there was no binding with the ILPR, bcl-2, and c-kit G-quadruplexes. This is the first time that a flexible cyclic polyamide was found to have high selectivity for the c-myb G-quadruplex.