A Potent, Water-Soluble and Photoinducible DNA Cross-Linking Agent
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- 作者：Ping Wang ; Renpeng Liu ; Xiaojun Wu ; Hongjuan Ma ; Xiaoping Cao ; Ping Zhou ; Jiangye Zhang ; Xiaocheng Weng ; Xiao-Lian Zhang ; Jun Qi ; Xiang Zhou ; and Linhong Weng
- 刊名：Journal of the American Chemical Society
- 出版年：2003
- 出版时间：February 5, 2003
- 年：2003
- 卷：125
- 期：5
- 页码：1116 - 1117
- 全文大小：53K
- 年卷期：v.125,no.5(February 5, 2003)
- ISSN：1520-5126
文摘
Water-soluble DNA cross-linking phenol and biphenol derivatives 3 and 6 have been synthesized by a Mannich reaction. Both of them can cross-link DNA by photoactivation using visible light (wavelength > 400 nm). Compound 6 can cross-link DNA at pH 5.0 and 7.7, whereas no cross-link was observed at pH 10.0. Density functional theory (DFT) calculation indicated that 6 displays a twist structure. Therefore, it could bind to DNA naturally and has potent property to cross-link DNA after photoactivation.