Convenient One-Step Synthesis of Benzo[c]phenanthridines by Three-Component Reactions of Isochromenylium Tetrafluoroborates and Stilbenes in Acetonitrile

详细信息    查看全文

• 作者：Gang-Gang Chen ; Jun-Qiang Wei ; Xiaoliang Yang ; Zhu-Jun Yao
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：April 1, 2016
• 年：2016
• 卷：18
• 期：7
• 页码：1502-1505
• 全文大小：339K
• ISSN：1523-7052

文摘

A new type of three-component reaction of air-stable isochromenylium tetrafluoroborates with electron-rich stilbenes in acetonitrile has been developed under catalyst-free conditions in this work. This cascade multibond-formation reaction is initiated by an intermolecular oxa [4 + 2]-cycloaddition, relayed with a nucleophilic addition of acetonitrile, and terminated by an intramolecular Friedel–Crafts reaction, affording the corresponding benzo[c]phenanthridine analogues in one step.