We report reversible phase transitions of ZnO nanowires subjected to high-pressure diamond anvil cell experiments. It was found that Mn doping obviously changes the elastic stability of ZnO nanowires and leads to low critical pressures of the reversible transitions between wurtzite to rocksalt phases during compression and decompression. First-principles calculations demonstrate that the lower critical pressures caused by Mn doping are associated with the decrease of internal energy difference and the increase of relative volume change between wurtzite to rocksalt phases.