Hybrid Isoprenoids from a Reeds Rhizosphere Soil Derived Actinomycete Streptomyces sp. CHQ-64

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• 作者：Qian Che ; Tianjiao Zhu ; Xin Qi ; Attila M谩ndi ; Tibor Kurt谩n ; Xiaomei Mo ; Jing Li ; Qianqun Gu ; Dehai Li
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：July 6, 2012
• 年：2012
• 卷：14
• 期：13
• 页码：3438-3441
• 全文大小：270K
• 年卷期：v.14,no.13(July 6, 2012)
• ISSN：1523-7052

文摘

Indotertine A (1), a hybrid isoprenoid with a condensed pentacyclic skeleton, together with two related hybrid isoprenoids, drimentines F (2) and G (3), were isolated from a reeds rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64. Their structures including absolute configurations were elucidated by spectroscopic methods, X-ray single crystal diffraction analysis, and TDDFT ECD calculations. Drimentines G (3) showed strong cytotoxicity against human cancer cells lines with IC₅₀'s down to 1.01 渭M, while 1 and 2 showed no significant activity.