Propargylamine Synthesis by Copper-Catalyzed Oxidative Coupling of Alkynes and Tertiary Amine N-Oxides

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• 作者：Zhanwei Xu ; Xiaoqiang Yu ; Xiujuan Feng ; Ming Bao
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：August 19, 2011
• 年：2011
• 卷：76
• 期：16
• 页码：6901-6905
• 全文大小：799K
• 年卷期：v.76,no.16(August 19, 2011)
• ISSN：1520-6904

文摘

An efficient method for synthesizing N,N-dimethylpropargylamines is described. The synthesis exploited the Cu(II)-catalyzed oxidative alkynylation reaction of trimethylamine N-oxides with alkynes in the absence of external oxidant. Both aromatic and aliphatic alkynes were utilized to achieve the corresponding products in moderate to excellent yields. The reaction conditions tolerated ester, hydroxy, and aldehyde groups.