Synthesis of Benzoxazoles from 2-Aminophenols and 尾-Diketones Using a Combined Catalyst of Br酶nsted Acid and Copper Iodide

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• 作者：Muhammad Shareef Mayo ; Xiaoqiang Yu ; Xiaoyu Zhou ; Xiujuan Feng ; Yoshinori Yamamoto ; Ming Bao
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：July 3, 2014
• 年：2014
• 卷：79
• 期：13
• 页码：6310-6314
• 全文大小：343K
• ISSN：1520-6904

文摘

Cyclization reactions of 2-aminophenols with 尾-diketones catalyzed by a combination of Br酶nsted acid and CuI are presented. Various 2-substituted benzoxazoles were obtained through these reactions. Different substituents such as methyl, chloro, bromo, nitro, and methoxy on 2-aminophenol are tolerated under the optimized reaction conditions.