Total Synthesis of (+)-Przewalskin B

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• 作者：Xiaotao Zhuo ; Kai Xiang ; Fu-Min Zhang ; Yong-Qiang Tu
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：August 19, 2011
• 年：2011
• 卷：76
• 期：16
• 页码：6918-6924
• 全文大小：871K
• 年卷期：v.76,no.16(August 19, 2011)
• ISSN：1520-6904

文摘

An efficient strategy for the total synthesis of (+)-przewalskin B is reported. The key steps feature an intermolecular S_N2鈥?substitution of iodoallylic phosphate with organocupper reagent, a diastereoselective organocatalytic aldol cyclization, as well as a Rh₂(OAc)₄-mediated intramolecular carbene insertion to the tertiary C鈥揌 bond.