An Investigation of the Mechanisms of Electronic Sensing of Protein Adsorption on Carbon Nanotube Devices

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• 作者：Robert J. Chen ; Hee Cheul Choi ; Sarunya Bangsaruntip ; Erhan Yenilmez ; Xiaowu Tang ; Qian Wang ; Ying-Lan Chang ; and Hongjie Dai
• 刊名：Journal of the American Chemical Society
• 出版年：2004
• 出版时间：February 11, 2004
• 年：2004
• 卷：126
• 期：5
• 页码：1563 - 1568
• 全文大小：226K
• 年卷期：v.126,no.5(February 11, 2004)
• ISSN：1520-5126

文摘

It has been reported that protein adsorption on single-walled carbon nanotube field effecttransistors (FETs) leads to appreciable changes in the electrical conductance of the devices, a phenomenonthat can be exploited for label-free detection of biomolecules with a high potential for miniaturization. Thiswork presents an elucidation of the electronic biosensing mechanisms with a newly developed microarrayof nanotube "micromat" sensors. Chemical functionalization schemes are devised to block selectedcomponents of the devices from protein adsorption, self-assembled monolayers (SAMs) of methoxy(poly(ethylene glycol))thiol (mPEG-SH) on the metal electrodes (Au, Pd) and PEG-containing surfactants onthe nanotubes. Extensive characterization reveals that electronic effects occurring at the metal-nanotubecontacts due to protein adsorption constitute a more significant contribution to the electronic biosensingsignal than adsorption solely along the exposed lengths of the nanotubes.