Synthesizing Substituted 2-Amino-2-chromenes Catalyzed by Tertiaryamine-Functionalized Polyacrylonitrile Fiber for Students To Investigate Multicomponent Reactions and Heterogeneous Catalysis
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- 作者：Yujia Xie ; Xiaoxing Liu ; Minli Tao
- 刊名：Journal of Chemical Education
- 出版年：2016
- 出版时间：December 13, 2016
- 年：2016
- 卷：93
- 期：12
- 页码：2074-2079
- 全文大小：327K
- ISSN：1938-1328
文摘
A multistep experiment for a synthesis laboratory course that incorporates topics in organic synthesis, chemical analysis, and instrumental analysis was developed. Students prepared a tertiaryamine-functionalized polyacrylonitrile fiber (PANTF), and it was subsequently utilized as an immobilized catalyst in a three-component condensation reaction among an aromatic aldehyde, malononitrile, and α-naphthol in ethanol to synthesize substituted 2-amino-2-chromenes in one pot. The fiber catalyst exhibits the advantages of high yield, excellent recyclability and reusability, simple post-treatment, and environmental friendliness. Thus, students were able to apply the concept of green chemistry through catalysis. Moreover, this comprehensive experiment involves a number of unit operations, such as vacuum distillation, filtration, recrystallization, and acid–base titration, which can train the fundamental operation capability of students, and improve their experimental skills.