Spirastrellolide B: Construction of the C(26)鈥揅(40) Northern Hemisphere and a Related [5,5,7]-Bis-spiroketal Analogue
文摘
Differential synthetic access to an advanced C26鈥揅40 northern hemisphere fragment of spirastrellolide B and to a related [5,5,7]-bis-spiroketal analogue from a common intermediate has been achieved. Central to this venture is the regiocontrolled functionalization of a C(31鈥?2) alkyne, exploiting different transition metal catalysts (cf. PtII and AuI).