Innovative Approach to the Accumulation of Rubrosterone by Fermentation of Asparagus filicinus with Fusarium oxysporum

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• 作者：Ying Li ; Le Cai ; Jian-Wei Dong ; Yun Xing ; Wei-He Duan ; Hao Zhou ; Zhong-Tao Ding
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：July 29, 2015
• 年：2015
• 卷：63
• 期：29
• 页码：6596-6602
• 全文大小：360K
• ISSN：1520-5118

文摘

Rubrosterone, possessing various remarkable bioactivities, is an insect-molting C₁₉-steroid. However, only very small amounts are available for biological tests due to its limited content from plant sources. Fungi of genus Fusarium have been reported to have the ability to convert C₂₇-steroids into C₁₉-steroids. In this study, Asparagus filicinus, containing a high content of 20-hydroxyecdysone, was utilized to accumulate rubrosterone through solid fermentation by Fusarium oxysporum. The results showed that F. oxysporum had the ability to facilitate the complete biotransformation of 20-hydroxyecdysone to rubrosterone by solid-state fermentation. The present method could be an innovative and efficient approach to accumulate rubrosterone with an outstanding conversion ratio.