Palladium-Catalyzed Domino Heck/Intermolecular C–H Bond Functionalization: Efficient Synthesis of Alkylated Polyfluoroarene Derivatives

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• 作者：Xin-Xing Wu ; Wen-Long Chen ; Yi Shen ; Si Chen ; Peng-Fei Xu ; Yong-Min Liang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：April 15, 2016
• 年：2016
• 卷：18
• 期：8
• 页码：1784-1787
• 全文大小：448K
• 年卷期：0
• ISSN：1523-7052

文摘

An efficient palladium-catalyzed alkylation of electron-deficient polyfluoroarenes is described. The protocol provides a useful and operationally simple access to a broad scope of alkylated polyfluoroarene derivatives in moderate to excellent yields. This also represents the first example of the introduction of a polyfluoroarene structure involving an alkylpalladium(II) intermediate.