Organocatalytic Asymmetric 1,4-Addition of Aldehydes to Acridiniums Catalyzed by a Diarylprolinol Silyl Ether

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• 作者：Tao Liang ; Jian Xiao ; Zhiyi Xiong ; Xingwei Li
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：April 6, 2012
• 年：2012
• 卷：77
• 期：7
• 页码：3583-3588
• 全文大小：248K
• 年卷期：v.77,no.7(April 6, 2012)
• ISSN：1520-6904

文摘

The organocatalytic enantioselective 1,4-addition of aldehydes to acridiniums catalyzed by diarylprolinol silyl ether was achieved to furnish chiral acridanes in both high yields (82鈥?6%) and excellent enantioselectivities (up to 99% ee), which also provides the highly enantioselective intermolecular 伪-alkylation of aldehydes with acridiniums salt.