Copper-Catalyzed Cyclopropanol Ring Opening Csp3鈥揅sp3 Cross-Couplings with (Fluoro)Alkyl Halides

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• 作者：Zhishi Ye ; Kristen E. Gettys ; Xingyu Shen ; Mingji Dai
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：December 18, 2015
• 年：2015
• 卷：17
• 期：24
• 页码：6074-6077
• 全文大小：444K
• ISSN：1523-7052

文摘

Novel and general copper-catalyzed cyclopropanol ring opening cross-coupling reactions with difluoroalkyl bromides, perfluoroalkyl iodides, monofluoroalkyl bromides, and 2-bromo-2-alkylesters to synthesize various 尾-(fluoro)alkylated ketones are reported. The reactions feature mild conditions and excellent functional group compatibility and can be scaled up to gram scale. Preliminary mechanistic studies suggest the involvement of radical intermediates. The difluoroalkyl鈥揳lkyl cross-coupling products can also be readily converted to more valuable and diverse gem-difluoro-containing compounds by taking advantage of the carbonyl group resulting from cyclopropanol ring opening.