Copper-Mediated Remote C鈥揌 Bond Chalcogenation of Quinolines on the C5 Position

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• 作者：Longzhi Zhu ; Renhua Qiu ; Xin Cao ; Song Xiao ; Xinhua Xu ; Chak-Tong Au ; Shuang-Feng Yin
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 20, 2015
• 年：2015
• 卷：17
• 期：22
• 页码：5528-5531
• 全文大小：378K
• ISSN：1523-7052

文摘

An efficient and convenient method is developed for the remote C鈥揌 bond chalcogenation of 8-aminoquinoline scaffolds on the C5 position that is geometrically inaccessible. The protocol makes use of inexpensive CuBr₂ as mediator and shows good tolerance toward numerous disulfides/diselenides and aliphatic amides, giving the corresponding products in good to excellent yield.