Use of Polyion Complexation for Polymerization-Induced Self-Assembly in Water under Visible Light Irradiation at 25 掳C

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• 作者：Qiuping Yu ; Yi Ding ; Hui Cao ; Xinhua Lu ; Yuanli Cai
• 刊名：ACS Macro Letters
• 出版年：2015
• 出版时间：November 17, 2015
• 年：2015
• 卷：4
• 期：11
• 页码：1293-1296
• 全文大小：385K
• ISSN：2161-1653

文摘

Polyion complexation (PIC) as the driving force of polymerization-induced self-assembly (PISA), that is, PIC鈥揚ISA, is explored. Reversible addition鈥揻ragmentation chain transfer (RAFT) dispersion polymerization of NH₃⁺-monomer 2-aminoethylacrylamide hydrochloride (AEAM) can be achieved in water under visible light irradiation at 25 掳C, using nonionic poly2-hydroxypropylmethacrylamide (PHPMA) macromolecular chain transfer agent in the presence of anionic poly(sodium 2-acrylamido-2-methylpropanesulfonate) (PAMPS) PIC-template. Sphere-to-network transition occurs, owing to the PIC of PAMPS with growing chains upon reaction close to isoelectric point (IEP); thereafter, the increase of electrostatic repulsion promotes the split of networks and the rupture of spheres into fragments. Therefore, the free-flowing solution becomes viscous liquid and free-standing physical gel, and then back into viscous and free-flowing liquid. Such a PIC鈥揚ISA is appealing for gene delivery because the size and surface charge are variable on demand and at high solids.