Rh-Catalyzed Construction of Quinolin-2(1H)-ones via C鈥揌 Bond Activation of Simple Anilines with CO and Alkynes

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• 作者：Xinyao Li ; Xinwei Li ; Ning Jiao
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：July 29, 2015
• 年：2015
• 卷：137
• 期：29
• 页码：9246-9249
• 全文大小：459K
• ISSN：1520-5126

文摘

A novel and efficient Rh-catalyzed carbonylation and annulation of simple anilines with CO and alkynes through N鈥揌 and C鈥揌 bond activation for the direct synthesis of quinolin-2(1H)-ones has been developed. Simple anilines without preactivation, broad substrate scope with hetero/polycycles, and high-value products make this protocol very practical and attractive. A key rhodacycle complex was isolated and well-characterized.