Structure and Cytotoxicity of Diterpenoids from Isodon eriocalyx

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• 作者：Xiao-Nian Li ; Jian-Xin Pu ; Xue Du ; Li-Guang Lou ; Li-Mei Li ; Sheng-Xiong Huang ; Bo Zhao ; Mei Zhang ; Fei He ; Xiao Luo ; Wei-Lie Xiao ; Han-Dong Sun
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：November 29, 2010
• 年：2010
• 卷：73
• 期：11
• 页码：1803-1809
• 全文大小：272K
• 年卷期：v.73,no.11(November 29, 2010)
• ISSN：1520-6025

文摘

A new ent-atisanoid, eriocatisin A (1), six new ent-abietanoids, eriocasins B−E (2−4, 7), 3-acetyleriocasin C (5), and 3β-acetoxyeriocasin D (6), and seven new ent-kauranoids, maoesins A−F (8, 10−14) and 3α-acetoxy-maoesin A (9), together with 21 known compounds, were isolated from the aerial parts of Isodon eriocalyx. The structures of 1−14 were determined by spectroscopic data interpretation. All compounds isolated were evaluated for their in vitro growth inhibitory activity against the HT-29, BEL-7402, and SK-OV-3 human cancer cell lines. Compounds 17, 18, and 20 showed inhibitory effects for all three tumor cell lines used, with IC₅₀ values in the range 2.1−7.3 μM.