Bisindole Alkaloids with Neural Anti-inflammatory Activity from Gelsemium elegans
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- 作者：Jing Qu ; Lei Fang ; Xiao-Dong Ren ; Yunbao Liu ; Shi-Shan Yu ; Li Li ; Xiu-Qi Bao ; Dan Zhang ; Yong Li ; Shuang-Gang Ma
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：December 27, 2013
- 年：2013
- 卷：76
- 期：12
- 页码：2203-2209
- 全文大小：377K
- ISSN：1520-6025
文摘
Three new trace bisindole alkaloids geleganimines A and B (1, 2) and geleganamide (3) were isolated from the aerial parts of Gelsemium elegans. Their structures were elucidated by spectroscopy, particularly from their carbon鈥損roton coupling constants, and electronic circular dichroism. Compounds 1鈥?b>3 are the first bisindole alkaloids discovered from the genus Gelsemium. Geleganimine B exhibited anti-inflammatory activity indirectly by suppressing lipopolysaccharide-induced pro-inflammatory factors in BV2 microglial cells with an IC50 value of 10.2 渭M. These findings confirm the importance of bioactive trace components in medicinal plant research.