Synthesis and Characterization of Biodegradable Hyperbranched Poly(ester-amide)s Based on Natural Material
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- 作者：Xiuru Li ; Yali Su ; Qingyong Chen ; Ying Lin ; Yuejin Tong ; and Yuesheng Li
- 刊名：Biomacromolecules
- 出版年：2005
- 出版时间：November 2005
- 年：2005
- 卷：6
- 期：6
- 页码：3181 - 3188
- 全文大小：177K
- 年卷期：v.6,no.6(November 2005)
- ISSN：1526-4602
文摘
A series of novel AB3-type monomers were prepared from nontoxic natural gallic acid and amino acids.These monomers were then melt-polycondensed in the presence of MgO as a catalyst via a transesterificationprocess at 170-190 
C to yield the hyperbranched poly(ester-amide)s bearing terminal acetyl groups. FTIRand NMR spectra confirmed the structures of all the monomers and polymers. The degrees of branching,estimated from 1H NMR and quantitative 13C NMR spectra, were 0.50-0.68. These hyperbranched polymersdisplayed moderately high molecular weights. Hydrolytic and enzymatic degradation studies were carriedout in vitro at 37.5 C in NaOH hydrotropic solution and in Tris-HCl buffer (pH = 8.6) containing proteinaseK, respectively. The results indicate that the hyperbranched poly(ester-amide)s are degradable hydrolyticallyas well as enzymatically, and the rate of hydrolytic degradation increases with the pH value of the solution.
C to yield the hyperbranched poly(ester-amide)s bearing terminal acetyl groups. FTIRand NMR spectra confirmed the structures of all the monomers and polymers. The degrees of branching,estimated from 1H NMR and quantitative 13C NMR spectra, were 0.50-0.68. These hyperbranched polymersdisplayed moderately high molecular weights. Hydrolytic and enzymatic degradation studies were carriedout in vitro at 37.5 C in NaOH hydrotropic solution and in Tris-HCl buffer (pH = 8.6) containing proteinaseK, respectively. The results indicate that the hyperbranched poly(ester-amide)s are degradable hydrolyticallyas well as enzymatically, and the rate of hydrolytic degradation increases with the pH value of the solution.