A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease
We report herein the identification of the rhodium(III) complex [Rh(phq)b>2b>(MOPIP)]+ (<b>1b>) as a potent and selective ATP-competitive neural precursor cell expressed, developmentally down-regulated 8 (NEDD8)-activating enzyme (NAE) inhibitor. Structure–activity relationship analysis indicated that the overall organometallic design of complex <b>1b> was important for anti-inflammatory activity. Complex <b>1b> showed promising anti-inflammatory activity in vivo for the potential treatment of inflammatory bowel disease.