High-Performance Liquid Chromatographic Enantioseparation of Racemic Drugs Based on Homochiral Metal鈥揙rganic Framework

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• 作者：Xuan Kuang ; Yu Ma ; Hao Su ; Jine Zhang ; Yu-Bin Dong ; Bo Tang
• 刊名：Analytical Chemistry
• 出版年：2014
• 出版时间：January 21, 2014
• 年：2014
• 卷：86
• 期：2
• 页码：1277-1281
• 全文大小：350K
• ISSN：1520-6882

文摘

Homochiral metal鈥搊rganic frameworks with fine-tuned pore sizes/walls and large surface areas are promising porous materials for enantioseparation considering the traditional zeolite molecular sieves have no chirality. Using enantiopure pyridyl-functionalized salen [(N-(4-Pyridylmethyl)-l-leucine路HBr)] as a starting material, we have prepared a noninterpenetrated three-dimensional homochiral metal organic framework {[ZnLBr]路H₂O}_n, which was further used as a chiral stationary phase for high-performance liquid chromatography to enantioseparate racemic drugs, showing excellent performances in enantioseparation of drugs. The metal鈥搊rganic framework can be regarded as a novel molecular sieve-like material with a chiral separation function based on the relative sizes of the chiral channels and the resolved molecules.