Polyketides with New Delhi Metallo-尾-lactamase 1 Inhibitory Activity from Penicillium sp.

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• 作者：Maoluo Gan ; Yufeng Liu ; Yinlei Bai ; Yan Guan ; Li Li ; Rongmei Gao ; Weiying He ; Xuefu You ; Yuhuan Li ; Liyan Yu ; Chunling Xiao
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：September 27, 2013
• 年：2013
• 卷：76
• 期：9
• 页码：1535-1540
• 全文大小：272K
• 年卷期：v.76,no.9(September 27, 2013)
• ISSN：1520-6025

文摘

Three new polyketide compounds (1鈥?), a new quinolone alkaloid (4), and seven known polyketide derivatives were identified from the cultures of Penicillium sp. I09F 484, a strain isolated from the rhizosphere soil of the plant Picea asperata from Kanas Lake, Xinjiang, China. Their structures were elucidated by extensive spectroscopic data analysis. The absolute configurations of 1 and 4 were established by quantum chemical time-dependent density functional theory electronic circular dichroism calculation and Marfey鈥檚 method, respectively. Compounds 1 and 2 displayed inhibitory activity against New Delhi metallo-尾-lactamase 1 with IC₅₀ values of 94.9 and 87.9 渭M, respectively.