In Situ Generated HypoIodite Activator for the C2 Sulfonylation of Heteroaromatic N-oxides
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- 作者：Yuan Su ; Xuejun Zhou ; Chunlian He ; Wei Zhang ; Xiao Ling ; Xia Xiao
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：June 17, 2016
- 年：2016
- 卷：81
- 期：12
- 页码：4981-4987
- 全文大小：476K
- 年卷期：0
- ISSN：1520-6904
文摘
A mild approach for direct C2 sulfonylation of heteroaromatic N-oxides with sulfonyl hydrazides affording 2-sulfonyl quinolines/pyridines has been developed. A variety of heteroaromatic N-oxides and sulfonyl hydrazides participate effectively in this transformation which uses hypoiodites (generated in situ from NaI and TBHP) as a means of substrate activators. In this reaction, the N-oxide plays a dual role, acting as a traceless directing group as well as a source of oxygen atom.