Dual-Responsive Controlled Drug Delivery Based on Ionically Assembled Nanoparticles

详细信息    查看全文

• 作者：Wei Cui ; Xuemin Lu ; Kun Cui ; Lvye Niu ; Yen Wei ; Qinghua Lu
• 刊名：Langmuir
• 出版年：2012
• 出版时间：June 26, 2012
• 年：2012
• 卷：28
• 期：25
• 页码：9413-9420
• 全文大小：433K
• 年卷期：v.28,no.25(June 26, 2012)
• ISSN：1520-5827

文摘

Ionically assembled nanoparticles (INPs) have been formed from poly(ionic liquid-co-N-isopropylacrylamide) with deoxycholic acid through electrostatic interaction. The structure and properties of the INPs were investigated by using ¹H NMR, Fourier transform infrared (FTIR), transmission electron microscopy (TEM), dynamic light scattering (DLS), and so on. Due to pH-responsive deoxycholic acid (pK_a = 6.2) and thermo responsive N-isopropylacrylamide included in the ionic complex, the INPs exhibit highly pH and thermal dual-responsive properties. The potential practical applications as drug delivery carriers were demonstrated using doxorubicin (DOX) as a model drug. With a lower pH (pH 5.2) and higher temperature (above 37 掳C), structural collapse of the INPs occurred as well as release of DOX owing to protonated DA departure from the INPs and a lower LCST (lower critical solution temperature) at the pathological conditions. The result shows that 80% of DOX molecules were released from INPs within 48 h at pH 5.2, 43 掳C, but only 30% of the drug was released within 48 h at 37 掳C and pH 7.4. Moreover, drug-loaded INPs exhibit an inhibitory effect on cell growth.