Efficient Palladium-Catalyzed C鈥揌 Fluorination of C(sp3)鈥揌 Bonds: Synthesis of 尾-Fluorinated Carboxylic Acids

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• 作者：Qihua Zhu ; Dezhong Ji ; Tingting Liang ; Xueyan Wang ; Yungen Xu
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：17
• 期：15
• 页码：3798-3801
• 全文大小：388K
• ISSN：1523-7052

文摘

A novel and facile process for direct fluorination of unactivated C(sp3)鈥揌 bonds at the 尾 position of carboxylic acids was accomplished by a palladium(II)-catalyzed C鈥揌 activation. The addition of Ag₂O and pivalic acid was found to be crucial for the success of this transformation. This reaction provides a versatile strategy for the synthesis of 尾-fluorinated carboxylic acids.