Tandem Chloropalladation/Cyclization and Dearomative Cyclization toward Functionalized Tricyclic Bridged [3.2.1] Skeleton Compounds

详细信息    查看全文

• 作者：Yi Dong ; Nana Du ; Xueyuan Li ; Litao Zheng ; Gang Liu
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 21, 2015
• 年：2015
• 卷：17
• 期：16
• 页码：4110-4113
• 全文大小：447K
• ISSN：1523-7052

文摘

A palladium-catalyzed tandem reaction is reported that involves chloropalladation/cyclization and dearomative cyclization to construct a tricyclic bridged [3.2.1] carbocyclic-skeleton and oxa- and aza-skeletons. In this domino process, a level of ring strain and other competitive reactions, i.e., protonolysis, 尾-hydride elimination, and chlorination of the C鈥揚d bond, were suppressed to the lowest level under mild reaction conditions.