Redox-Neutral Couplings between Amides and Alkynes via Cobalt(III)-Catalyzed C–H Activation

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• 作者：Lingheng Kong ; Songjie Yu ; Xukai Zhou ; Xingwei Li
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：February 5, 2016
• 年：2016
• 卷：18
• 期：3
• 页码：588-591
• 全文大小：360K
• ISSN：1523-7052

文摘

C–H activation assisted by a bifunctional directing group has allowed the construction of heterocycles. This is ideally catalyzed by earth-abundant and eco-friendly transition metals. We report Co(III)-catalyzed redox-neutral coupling between arenes and alkynes using an NH amide as an electrophilic directing group. The redox-neutral C–H activation/coupling afforded quinolines with water as the sole byproduct.