Synthesis of 8-Desbromohinckdentine A1

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• 作者：Yahua Liu and William W. McWhorter ; Jr.
• 刊名：Journal of the American Chemical Society
• 出版年：2003
• 出版时间：April 9, 2003
• 年：2003
• 卷：125
• 期：14
• 页码：4240 - 4252
• 全文大小：268K
• 年卷期：v.125,no.14(April 9, 2003)
• ISSN：1520-5126

文摘

Hinckdentine A is an alkaloid isolated from the bryozoan Hincksinoflustra denticulate. This naturalproduct contains a novel and unique 11b,12,13,14,15,16-hexahydroazepino[4',5':2,3]indolo[1,2-c]quinazolinering system that has not previously been synthesized. We have synthesized 8-desbromohinckdentine Afrom a 2-aryl indole by first preparing the quaternary center of the natural product and then building theseven-membered lactam and dihydropyrimidine rings onto this intermediate to form the framework ofhinckdentine A.