Copper-Catalyzed Carbonylative Synthesis of Aliphatic Amides from Alkanes and Primary Amines via C(sp3)–H Bond Activation

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• 作者：Yahui Li ; Fengxiang Zhu ; Zechao Wang ; Xiao-Feng Wu
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：August 5, 2016
• 年：2016
• 卷：6
• 期：8
• 页码：5561-5564
• 全文大小：314K
• 年卷期：0
• ISSN：2155-5435

文摘

Amides are important intermediates and building blocks in organic synthesis. Among the known preparation procedures, aminocarbonylation is an interesting and powerful tool. However, most of the studies were focused on noble metal-catalyzed synthesis of aromatic amides. Herein, we describe an attractive copper-catalyzed synthesis of aliphatic amides from alkanes and amines. A variety of amides were prepared in good yields by carbonylation of the C_(sp3)–H bond of alkanes with different amines. Good functional groups tolerance can be observed.