Copper/Manganese Cocatalyzed Oxidative Coupling of Vinylarenes with Ketones
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- 作者：Xing-Wang Lan ; Nai-Xing Wang ; Wei Zhang ; Jia-Long Wen ; Cui-Bing Bai ; Yalan Xing ; Yi-He Li
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：September 18, 2015
- 年：2015
- 卷：17
- 期：18
- 页码：4460-4463
- 全文大小：326K
- ISSN：1523-7052
文摘
A novel copper/manganese cocatalyzed direct oxidative coupling of terminal vinylarenes with ketones via C(sp3)鈥揌 bond functionalization following C鈥揅 bond formation has been developed using tert-butyl hydroperoxide as the radical initiator. Various ketones underwent a free-radical addition of terminal vinylarenes to give the corresponding 1,4-dicarbonyl products with excellent regioselectivity and efficiency through one step. A possible reaction mechanism has been proposed.