N-Heterocyclic Carbene Organocatalytic Reductive 尾,尾-Coupling Reactions of Nitroalkenes via Radical Intermediates

详细信息    查看全文

• 作者：Yu Du ; Yuhuang Wang ; Xin Li ; Yaling Shao ; Guohui Li ; Richard D. Webster ; Yonggui Robin Chi
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 7, 2014
• 年：2014
• 卷：16
• 期：21
• 页码：5678-5681
• 全文大小：430K
• ISSN：1523-7052

文摘

An unprecedented N-heterocyclic carbene catalytic reductive 尾,尾-carbon coupling of 伪,尾-nitroalkenes, by using an organic substrate to mimic the one-electron oxidation role of the pyruvate ferredoxin oxidoreductase (PFOR) in living systems, has been developed. The reaction goes through a radical anion intermediate generated under a catalytic redox process. For the first time, the presence of radical anion intermediate in NHC organocatalysis is observed and clearly verified.