Striking Difference between Succinimidomethyl and Phthalimidomethyl Radicals in Conjugate Addition to Alkylidenemalonate Initiated by Dimethylzinc

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• 作者：Ken-ichi Yamada ; Yusuke Matsumoto ; Shintaro Fujii ; Takehito Konishi ; Yousuke Yamaoka ; Kiyosei Takasu
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：81
• 期：9
• 页码：3809-3817
• 全文大小：391K
• 年卷期：0
• ISSN：1520-6904

文摘

We used dimethylzinc to develop a conjugate addition reaction of imidomethyl radicals to alkylidenemalonates, in which we observed a significant difference between succinimidomethyl and phthalimidomethyl radicals. This reaction provides new access to γ-aminobutyric acid derivatives, which often function as neurotransmitters.