Silver-Catalyzed Incorporation of Carbon Dioxide into o-Alkynylaniline Derivatives

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• 作者：Tomonobu Ishida ; Satoshi Kikuchi ; Tatsuyuki Tsubo ; Tohru Yamada
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：February 15, 2013
• 年：2013
• 卷：15
• 期：4
• 页码：848-851
• 全文大小：245K
• 年卷期：v.15,no.4(February 15, 2013)
• ISSN：1523-7052

文摘

Benzoxazine-2-one derivatives are important heterocycle structures because of their various pharmaceutical activities, though their synthetic methods had been limited. In some cases, toxic reagents, such as phosgene or carbon monoxide, are required. It was found that a silver catalyst successfully promoted the incorporation of CO₂ into o-alkynylanilines to afford the corresponding benzoxazine-2-ones bearing Z exo-olefin via 6-exo-dig cyclization at the activated C鈥揅 triple bond.