Stereochemically Defined Various Multisubstituted Alkenes Bearing a Tetrafluoroethylene (−CF2CF2−) Fragment

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• 作者：Yukiho Sakaguchi ; Shigeyuki Yamada ; Tsutomu KonnoTomohiro Agou ; Toshio Kubota
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：February 3, 2017
• 年：2017
• 卷：82
• 期：3
• 页码：1618-1631
• 全文大小：717K
• ISSN：1520-6904

文摘

Highly regio- and stereoselective transformation of commercially available 4-bromo-3,3,4,4-tetrafluoro-1-butene into multisubstituted alkenes having a tetrafluoroethylene fragment through Heck reactions and/or Suzuki–Miyaura cross-coupling reactions was established. Thus, the obtained alkenes underwent a smooth reductive coupling reaction with aldehydes under the influence of MeLi/LiBr-free, affording structurally unprecedented fluorinated materials.